If you lob explosives of your own, avoid throwing them towards the stage - there are two NPCs here not involved with the fight, and you don’t want to hurt them. Move often to avoid getting hit by molotovs. Melee attacks don’t work so well, given how spread out your enemies are, so find a place to take cover and use V.A.T.S. The obvious way to clear the room is to just engage in a shootout.
